Structure of PDB 7dge Chain A

Receptor sequence
>7dgeA (length=784) Species: 9606 (Homo sapiens) [Search protein sequence]
QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFH
TLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLIGRTKKP
IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVV
PSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCI
AHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRR
LGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFL
KLRLDTNHRNPWFQEFWQHRFQCRLEGFPQENSNFKRICTGNESLEENYV
QDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI
KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVL
NIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEY
VQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGIL
VTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTT
SCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWA
QVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVA
PLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIY
FGSNYKIITTCFAVSLSVTVALGCMFTPKMYIII
3D structure
PDB7dge Structural insights into the activation initiation of full-length mGlu1.
ChainA
Resolution3.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QUS A Y74 W110 G163 S164 S165 S186 T188 Y236 E292 G319 R323 Y40 W76 G108 S109 S110 S131 T133 Y181 E237 G264 R268 BindingDB: Ki=10nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dge, PDBe:7dge, PDBj:7dge
PDBsum7dge
PubMed33278019
UniProtQ13255|GRM1_HUMAN Metabotropic glutamate receptor 1 (Gene Name=GRM1)

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