Structure of PDB 7dfz Chain A

Receptor sequence
>7dfzA (length=897) Species: 9606 (Homo sapiens) [Search protein sequence]
STHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVE
LWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKN
FSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTS
LYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLT
FKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPA
GDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAE
DLPIFATSYIVIFLYISLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQ
VVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLC
SLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSK
LLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELA
LPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCN
NFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNK
DKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPK
GGLAAYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANI
TADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAV
SCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVG
MSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILV
LGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPAL
3D structure
PDB7dfz Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake.
ChainA
Resolution3.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H56 A V380 L382 W383 I625 I698 A768 L871 L875 A876 F1101 V1166 L1234 F1239 V49 L51 W52 I294 I348 A418 L495 L499 A500 F725 V790 L858 F863
BS02 CLR A W351 L358 S359 S789 W20 L27 S28 S439
BS03 CLR A L690 F759 L340 F409
BS04 CLR A L370 T373 L39 T42
Gene Ontology
Molecular Function
GO:0005319 lipid transporter activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7dfz, PDBe:7dfz, PDBj:7dfz
PDBsum7dfz
PubMed34272236
UniProtQ9UHC9|NPCL1_HUMAN NPC1-like intracellular cholesterol transporter 1 (Gene Name=NPC1L1)

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