Structure of PDB 7deg Chain A

Receptor sequence

>7degA (length=581) Species: 224324 (Aquifex aeolicus VF5)

VSNAIKFIILTEIIFPTLLLVFGIYHGVMQVFYRSGIIKAESFLGIDYYQ
GLTLHGVINVIVYTTIFIVGFSNAIVAYSLKKPLREKVQWIALGMMVIGT
LMAAWAMFTGRATVLYTFYPPLIAHWTFYLGAVLLVLGSLVPFFFDWIPS
AIQWKRENPDQKLPLAVFGTFVNFILWTIMIVPVAIEILFQLLPLSLGLV
DEINPLLARTLFWFFGHPVVYFWLLPAYVALYTILPKIVSEKGKLYSDPA
ARLAFILFLIFSLPVGLHHQFTDPGITNTWKLIHALFTFGVALPSMITAF
TVATSLEYSVKAEHPELKNSKFYWWTFLPFMRLEGNKWMFSYFFAGLVLF
FIGGITGIVNASYNVNLVVHNTAYVPGHFHTTVGGLVLLVFFALSLYMVS
KLRGSEVKLKGLAVLAPYFWMQGMFMFSYAMMVGGVVVGFPRRTNAGLTY
LNPDSPLYRPEWTGYAQLAAVGGVLLAIGFAFYFASLIATALAPKVREST
LEFPIADAYHDAPAPLLNNLKTWTVAAIILAVLSYIPPLYDASVRGVFFK
SPAYNEKFPMGAEKKEEKKELSKAEGGITQK

3D structure

• PDB: 7deg The Unusual Homodimer of a Heme-Copper Terminal Oxidase Allows Itself to Utilize Two Electron Donors.
• Chain: A
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HAS	A	Y121 W218 V225 Y226 W228 L229 H273 H274 S300 A304 L352 F355 F356 G359 G362 N365 A366 N371 H375 H383 F384 T387 V388 R447	Y116 W213 V220 Y221 W223 L224 H268 H269 S295 A299 L347 F350 F351 G354 G357 N360 A361 N366 H370 H378 F379 T382 V383 R442
BS02	HEM	A	I29 G32 Q35 R39 Y53 H60 N64 Y121 F384 H385 V388 L393 W425 F432 R448 L481	I24 G27 Q30 R34 Y48 H55 N59 Y116 F379 H380 V383 L388 W420 F427 R443 L476
BS03	CU	A	H222 H273 H274	H217 H268 H269
BS04	DLX	A	I357 F430 M437 V441	I352 F425 M432 V436

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0020037 heme binding

Biological Process

• GO:0009060 aerobic respiration
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7deg, PDBe:7deg, PDBj:7deg
• PDBsum: 7deg
• PubMed: 33665933
• UniProt: O67937