Structure of PDB 7de4 Chain A

Receptor sequence
>7de4A (length=550) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAV
KAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKA
QCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILG
LRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNAL
LECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHD
LKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQ
QVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGDDFS
AVITQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIF
LLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLP
RLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILL
TLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
3D structure
PDB7de4 Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion.
ChainA
Resolution3.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.7.99.1: hydroxylamine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A C3 V4 Q5 C6 T9 C18 G23 M24 C25 T75 C3 V4 Q5 C6 T9 C18 G23 M24 C25 T75
BS02 FS2 A H249 E273 W297 C317 C405 C433 C458 E492 K494 H249 E273 W297 C317 C405 C433 C458 E492 K494
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors
GO:0046872 metal ion binding
GO:0050418 hydroxylamine reductase activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0042542 response to hydrogen peroxide
GO:0046210 nitric oxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7de4, PDBe:7de4, PDBj:7de4
PDBsum7de4
PubMed34101368
UniProtP75825|HCP_ECOLI Hydroxylamine reductase (Gene Name=hcp)

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