Structure of PDB 7ddz Chain A

Receptor sequence

>7ddzA (length=437) Species: 882,9606

EVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADL
LVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALD
RYRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPD
FEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLK
NHVAKALIVYGSTTGNTEYTAETIARELADAGYEVDSRDAASVEAGGLFE
GFDLVLLGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKVACFGCGDSSW
EYFCGAVDAIEEKLKNLGAEIVQDGLRIDGDPRAARDDIVGWAHDVRGAI
DHYHQRRQKTTKMLVCVVVVFAVCWLPLHAFQLAVDIDSQVLDLKEYKLI
FTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCE

3D structure

• PDB: 7ddz Structural basis for ligand recognition of the neuropeptide Y Y 2 receptor.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	H46	A	T107 W116 P127 V134 L183 R187 S220 S223 L224 L227 H285 Q288 H311	T60 W69 P80 V87 L136 R140 S173 S176 L177 L180 H379 Q382 H405
BS02	FMN	A	S1008 T1009 T1010 N1012 T1013 S1056 T1057 W1058 G1092 D1093 W1096 F1099 C1100	S212 T213 T214 N216 T217 S260 T261 W262 G296 D297 W300 F303 C304

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity
• GO:0009055 electron transfer activity
• GO:0010181 FMN binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7ddz, PDBe:7ddz, PDBj:7ddz
• PDBsum: 7ddz
• PubMed: 33531491
• UniProt: P00323|FLAV_NITV2 Flavodoxin (Gene Name=DVU_2680);
  P49146|NPY2R_HUMAN Neuropeptide Y receptor type 2 (Gene Name=NPY2R)