Structure of PDB 7dbl Chain A

Receptor sequence
>7dblA (length=422) Species: 5074 (Penicillium brevicompactum) [Search protein sequence]
MSTEKFTITEHLVPGSHIREYPGSTVNQEDVLKIHVKQYTPKREGPVPDD
AITFIATHGVGLPKELYEPLWDELLDQASGFHIRAIWMADVASMNQSGIH
NEDKLSMDCSWMDHARDLLLMINHFRDQMPRPLVGIGHAFGGNIITNLAY
LHPRLFTTLLLLDPLIQLSPPSLGFGTDAPSAINYTLWRDDVWPSREVAI
RANRAIMQGMDPRCLDRMTKHFFRDLPTPLYPDVEAIKALFGTTADSTTT
PVTLTTPKYHELVAQIRQNFNARDPKTGRIEVPRDTHADMDPLVAYIPLY
RPEPRSTFRRLETLRPSCLWVIAGATFLNIDEIREGVKICGSGIGGSGGV
PDGRVREVVLPGFGHLMPFQEVKTVAETCIVWLQQEMDRFRQTERQWKED
RDGKSHLAVEENWYKVLKPIPS
3D structure
PDB7dbl Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis.
ChainA
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MOA A G59 V60 A139 F140 Q167 P171 I183 Q265 R301 P304 F327 H365 G59 V60 A139 F140 Q167 P171 I183 Q265 R301 P304 F327 H365
Gene Ontology
Molecular Function
GO:0016218 polyketide synthase activity
GO:0016787 hydrolase activity
GO:0047617 fatty acyl-CoA hydrolase activity
Biological Process
GO:0016114 terpenoid biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0072330 monocarboxylic acid biosynthetic process
GO:0140722 mycophenolic acid biosynthetic process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dbl, PDBe:7dbl, PDBj:7dbl
PDBsum7dbl
PubMed33843134
UniProtA0A0B5LB55|MPAH2_PENBR Type I acyl-CoA thioesterase mpaH' (Gene Name=mpaH')

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