Structure of PDB 7db8 Chain A

Receptor sequence
>7db8A (length=267) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DERLATLRAERDAAVLVAEGIDVTLPSTRVPAGARHPIIMLAEHVADTFI
AMGWELAEGPEVETEQFNFDALNFPADHPARGEQDTFYIAPEDSRQLLRT
HTSPVQIRTLLARELPVYIISIGRTFRTDELDATHTPIFHQVEGLAVDRG
LSMAHLRGTLDAFARAEFGPSARTRIRPHFFPFTEPSAEVDVWFANKIGG
AAWVEWGGCGMVHPNVLRATGIDPDLYSGFAFGMGLERTLQFRNGIPDMR
DMVEGDVRFSLPFGVGA
3D structure
PDB7db8 Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A R201 R312 R127 R238
BS02 SO4 A D206 A207 R324 D132 A133 R250
BS03 H2R A L146 S177 R201 F213 Q215 E217 L219 F255 F257 G282 C283 A305 F306 G307 G309 R312 L72 S103 R127 F139 Q141 E143 L145 F181 F183 G208 C209 A231 F232 G233 G235 R238
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7db8, PDBe:7db8, PDBj:7db8
PDBsum7db8
PubMed33397709
UniProtP9WFU3|SYFA_MYCTU Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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