Structure of PDB 7daw Chain A

Receptor sequence
>7dawA (length=267) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DERLATLRAERDAAVLVAEGIDVTLPSTRVPAGARHPIIMLAEHVADTFI
AMGWELAEGPEVETEQFNFDALNFPADHPARGEQDTFYIAPEDSRQLLRT
HTSPVQIRTLLARELPVYIISIGRTFRTDELDATHTPIFHQVEGLAVDRG
LSMAHLRGTLDAFARAEFGPSARTRIRPHFFPFTEPSAEVDVWFANKIGG
AAWVEWGGCGMVHPNVLRATGIDPDLYSGFAFGMGLERTLQFRNGIPDMR
DMVEGDVRFSLPFGVGA
3D structure
PDB7daw Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
ChainA
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A A207 R324 A133 R250
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7daw, PDBe:7daw, PDBj:7daw
PDBsum7daw
PubMed33397709
UniProtP9WFU3|SYFA_MYCTU Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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