Structure of PDB 7d9r Chain A

Receptor sequence
>7d9rA (length=502) Species: 9606 (Homo sapiens) [Search protein sequence]
SRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKFEKTIAEQAVAAGVP
VEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQASILCL
LHVYYFTTSLILPGIIKAAAHVLYETEVEVSLYLLYSVHSLVIPTSLFCK
TFPFHFMFDKDMTILQFGNGIRRLMNRRDKPNFEEYFEILTPKINQTFSG
IMTMLNMQFVVRVRRVMDLKGQMIYIVESSAILFLGSPCVLYLSDIPIHN
ALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSI
FPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLN
ALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMAVKMM
ELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF
ESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFL
DA
3D structure
PDB7d9r Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G2P A D486 I487 V488 G489 F490 T491 I528 G529 D530 R574 D329 I330 V331 G332 F333 T334 I371 G372 D373 R417
BS02 MG A D486 D530 D329 D373
BS03 MG A D486 I487 D329 I330
BS04 GZO A L425 R428 L268 R271
Gene Ontology
Molecular Function
GO:0004383 guanylate cyclase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0020037 heme binding
GO:0038023 signaling receptor activity
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009190 cyclic nucleotide biosynthetic process
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0019934 cGMP-mediated signaling
GO:0035556 intracellular signal transduction
GO:0038060 nitric oxide-cGMP-mediated signaling
GO:0060087 relaxation of vascular associated smooth muscle
GO:0070482 response to oxygen levels
GO:0098925 retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008074 guanylate cyclase complex, soluble
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7d9r, PDBe:7d9r, PDBj:7d9r
PDBsum7d9r
PubMed34535643
UniProtQ02108|GCYA1_HUMAN Guanylate cyclase soluble subunit alpha-1 (Gene Name=GUCY1A1)

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