Structure of PDB 7d8n Chain A

Receptor sequence
>7d8nA (length=625) Species: 9606 (Homo sapiens) [Search protein sequence]
SLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDIY
ISRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEPLPLAYAVLYLTCVD
ISLDCDLNCEGRVDKRQWVWGPSGYGGILLVNCDRDDPSCDVQDNCDQHV
HCLQDLEDMSVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICGPED
VCEAYRHVLGQDKVSYEVPRLHGDEERFFVEGLSFPDAGFTGLISFHVTL
LDDSNEDFSASPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVD
AVAELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSP
RNGELQDFPYKRILGPDFGYVTREPRDRLDSFGNLEVSPPVVANGKEYPL
GRILIGGNLPGSSGRRVTQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFL
SFVPAPDGKGFRMLLASPGACFKLFQEKQKCGHGRALLFQGVVDKTISIN
QVLSNKDLINYNKFVQSCIDWNREVLKRELGLAECDIIDIPQLFKTERKK
ATAFFPDLVNMLVLGKHLGIPKPFGPIINGCCCLEEKVRSLLEPLGLHCT
FIDDFTCGTNVCRKPFSFKWWNMVP
3D structure
PDB7d8n Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
ChainA
Resolution2.753 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D165 D168 H170 D144 D147 H149
BS02 CA A D155 D157 D179 D388 D134 D136 D158 D367
BS03 CA A E353 F407 L410 E411 E332 F382 L385 E386
BS04 CA A N153 D155 D157 D165 D176 D179 N132 D134 D136 D144 D155 D158
BS05 CA A R372 E395 R351 E374
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Cellular Component
External links
PDB RCSB:7d8n, PDBe:7d8n, PDBj:7d8n
PDBsum7d8n
PubMed33971157
UniProtQ9ULW8|PADI3_HUMAN Protein-arginine deiminase type-3 (Gene Name=PADI3)

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