Structure of PDB 7d7m Chain A

Receptor sequence
>7d7mA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
SPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLG
TLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERY
LAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDT
WCFIDWTTQVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFF
RRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNP
DLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIK
3D structure
PDB7d7m Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P2E A M27 T69 T76 Y80 T168 W169 L312 A318 S319 M9 T51 T58 Y62 T150 W151 L252 A258 S259 BindingDB: Ki=0.79nM,EC50=3nM,IC50=0.700000nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004955 prostaglandin receptor activity
GO:0004957 prostaglandin E receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7d7m, PDBe:7d7m, PDBj:7d7m
PDBsum7d7m
PubMed33264604
UniProtP35408|PE2R4_HUMAN Prostaglandin E2 receptor EP4 subtype (Gene Name=PTGER4)

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