Structure of PDB 7d74 Chain A

Receptor sequence
>7d74A (length=406) Species: 9606 (Homo sapiens) [Search protein sequence]
MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGM
QEILLIGFYQPDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRD
QILAGSPEAFFVLNADVCSDFPLSAMLEAHRRQRHPFLLLGTTANRTQSL
NYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRDVFQR
NQQGTIRLEQDVFSALAGQGQIYVHLTDGIWSQIKSAGSALYASRLYLSR
YQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVLGPNVSIGKGVTVG
EGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPNPND
PRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSF
TNQIIL
3D structure
PDB7d74 Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A L7 I8 G9 I56 F58 E85 G90 T91 N114 D116 Q247 L7 I8 G9 I56 F58 E85 G90 T91 N114 D116 Q233
Gene Ontology
Molecular Function
GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0019899 enzyme binding
Biological Process
GO:0006486 protein glycosylation
GO:0009058 biosynthetic process
GO:0009100 glycoprotein metabolic process
GO:0009298 GDP-mannose biosynthetic process
GO:0009890 negative regulation of biosynthetic process
GO:0019673 GDP-mannose metabolic process
GO:0021537 telencephalon development
GO:0045934 negative regulation of nucleobase-containing compound metabolic process
GO:0045936 negative regulation of phosphate metabolic process
GO:0048644 muscle organ morphogenesis
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0051402 neuron apoptotic process
GO:0060538 skeletal muscle organ development
GO:0061744 motor behavior
GO:0062014 negative regulation of small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome
GO:0120508 GDP-mannose pyrophosphorylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7d74, PDBe:7d74, PDBj:7d74
PDBsum7d74
PubMed33986552
UniProtQ96IJ6|GMPPA_HUMAN Mannose-1-phosphate guanyltransferase alpha (Gene Name=GMPPA)

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