Structure of PDB 7d5r Chain A

Receptor sequence
>7d5rA (length=619) Species: 9606 (Homo sapiens) [Search protein sequence]
LQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDIYI
SPNMERGRERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEP
LPLAYAVLYLTCVDISLDCDLNKRQWVWGPSGYGGILLVNCDRDDDNCDQ
HVHCLQDLEDMSVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICGP
EDVCEAYRHVLGQDKVSYEVPRLHGDEERFFVEGLSFPDAGFTGLISFHV
TLLDDDFSASPIFTDTVVFRVAPWIMTPSTLPPLEVYVCNTCFVDAVAEL
ARKAGCKLTICPQAWIQDEMELGYVQAPHKTLPVVFDSPRNLQDFPYKRI
LGPDFGYVTREPRGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGRRV
TQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFLSFVPAPDGKGFRMLLAS
PGACFKLFQEKQKCGHGRALLFQGVVDVKTISINQVLSNKDLINYNKFVQ
SCIDWNREVLKRELGLAECDIIDIPQLFKTERKKATAFFPDLVNMLVLGK
HLGIPKPFGPIINGCCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVH
AGTNVCRKPFSFKWWNMVP
3D structure
PDB7d5r Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
ChainA
Resolution3.148 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D157 D179 D388 D144 D160 D354
BS02 CA A Q349 E353 F407 L410 E411 Q317 E321 F368 L371 E372
BS03 CA A D369 S370 N373 D337 S338 N341
BS04 CA A N153 D155 D157 D165 D176 D179 N140 D142 D144 D146 D157 D160
BS05 CA A D165 D168 D176 D146 D149 D157
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Cellular Component
External links
PDB RCSB:7d5r, PDBe:7d5r, PDBj:7d5r
PDBsum7d5r
PubMed33971157
UniProtQ9ULW8|PADI3_HUMAN Protein-arginine deiminase type-3 (Gene Name=PADI3)

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