Structure of PDB 7d4p Chain A

Receptor sequence

>7d4pA (length=669) Species: 9606 (Homo sapiens)

RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVEC
VSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELS
KVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDLAKLKVA
IKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPM
LSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQDLHVQGP
PPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLA
TISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFT
ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAID
EPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTE
FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWM
SYFDEGGTLPPPFNIISLIQNQHYQEVIRNLVKRYVAAMIRNSKTTEENF
KELKQDISSFRYEVLDLLG

3D structure

• PDB: 7d4p Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GX0	A	Y374 F414 G417 D439 M442 N443 Y446 R492 L496 P659	Y331 F366 G369 D391 M394 N395 Y398 R444 L448 P611
BS02	Y01	A	Y316 F364 A499 N500	Y273 F321 A451 N452
BS03	ZN	A	H172 C176 C178 C181	H141 C145 C147 C150
BS04	CA	A	E418 E421 N436 D439	E370 E373 N388 D391
BS05	YZY	A	Y524 Q573 F576 W577	Y476 Q525 F528 W529
BS06	YZY	A	F599 V610	F551 V562

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7d4p, PDBe:7d4p, PDBj:7d4p
• PDBsum: 7d4p
• PubMed: 33683200
• UniProt: Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)