Structure of PDB 7d4n Chain A

Receptor sequence

>7d4nA (length=442) Species: 439493 (Candidatus Pelagibacter sp. HTCC7211)

MSKVAIIGAGPCGLSILRAFEHLEKKGEKIPEIVCFEKQESWGGLWNYNW
RTGSDQYGDPVPNSMYRYLWSNGPKECLEFADYSFDQHFGKSIPSFPPRE
VLQDYILGRVSKGNIKNKIKFNTRVINTVYRNDKFEINYQDKVNDKTLSD
TFDYLVVSTGHFSVPFIPEYEGMSSFPGRIMHSHDFRDAEEFRGKNVIVL
GSSYSAEDVALQCNKYGAKSVTIGYRHNPMGFKWPKGMKEVHYLDKLDGK
KAIFKDGTEQDADVVILCTGYLHHFPFLDESLKLKTHNRLYPPKLYKGVV
WQDNHKLLYLGMQDQFHTFNMFDCQAWFARDVIMDKIKMPSDDEIDKDIN
KWVSMEEKLENPDQMIDFQTEYTKELHNISDYPKIDFELIRKHFKEWEHH
KVEDILTYRNKSFSSPVTGSVAPVHHTPWEKAMDDSMKTFLN

3D structure

• PDB: 7d4n Structural and Mechanistic Insights Into Dimethylsulfoxide Formation Through Dimethylsulfide Oxidation.
• Chain: A
• Resolution: 1.999 Å

Enzymatic activity

• Enzyme Commision number: 1.14.13.148: trimethylamine monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	Y66 W70 N72 F162 P168 Y170 S202 S203 Y204 S205 D208 R226 H227 C268 T269 G270	Y66 W70 N72 F162 P168 Y170 S202 S203 Y204 S205 D208 R226 H227 C268 T269 G270
BS02	FAD	A	I7 G8 G10 P11 C12 F36 E37 K38 Q39 G44 L45 W46 M65 S71 N72 V125 T159 F162 F277 Q315 T318	I7 G8 G10 P11 C12 F36 E37 K38 Q39 G44 L45 W46 M65 S71 N72 V125 T159 F162 F277 Q315 T318

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0004499 N,N-dimethylaniline monooxygenase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0050661 NADP binding

External links

• PDB: RCSB:7d4n, PDBe:7d4n, PDBj:7d4n
• PDBsum: 7d4n
• PubMed: 34630359
• UniProt: B6BQB2|TMM_PELS7 Trimethylamine monooxygenase (Gene Name=tmm)