Structure of PDB 7d42 Chain A

Receptor sequence
>7d42A (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNH
VQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLSGHS
DLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDR
QYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNH
HHAEMLMSWRVNDHKFTPLLCEIWD
3D structure
PDB7d42 Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor.
ChainA
Resolution2.697 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V299 I317 L464 E467 V55 I73 L219 E222
BS02 GWF A M265 F284 L287 T288 A291 M328 F329 R331 S332 H447 F461 M21 F40 L43 T44 A47 M84 F85 R87 S88 H202 F216 BindingDB: EC50=0.200000nM
Gene Ontology
Molecular Function
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7d42, PDBe:7d42, PDBj:7d42
PDBsum7d42
PubMed33121679
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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