Structure of PDB 7d2l Chain A

Receptor sequence

>7d2lA (length=1077) Species: 1410628 (Lachnospiraceae bacterium ND2006) [Search protein sequence]

NASETRKAYTTKMIPRSHDRMKLLGNFMDYLMDGTPIFFELWNQFGGGID
RDIISGTANKDKISDDLLLAVNWFKVMPINSKPQGVSPSNLANLFQQYSG
SEPDIQAQEYFASNFDTEKHQWKDMRVEYERLLAELQLSRSDMHHDLKLM
YKEKCIGLSLSTAHYITSVMFGTGAKNNRQTKHQFYSKVIQLLEESTQIN
SVEQLASIILKAGDCDSYRKLRIRCSRKGATPSILKIVQDYELGTNHDDE
VNVPSLIANLKEKLGRFEYECEWKCMEKIKAFLASKVGPYYLGSYSAMLE
NALSPIKGMTTKNCKFVLKQIDAKNDIKYENEPFGKIVEGFFDSPYFESD
TNVKWVLHPHHIGESNIKTLWEDLNAIHSKYEEDIASLSEDKKEKRIKVY
QGDVCQTINTYCEEVGKEAKTPLVQLLRYLYSRKDDIAVDKIIDGITFLS
KKHKVEKQKINPVIQKYPSFNFGNNSKLLGKIISPKDKLKHNLKCNRNQV
DNYIWIEIKVLNTKTMRWEKHHYALSSTRFLEEVYYPATSENPPDALAAR
FRTKTNGYEGKPALSAEQIEQIRSAPVGLRKVKKRQMRLEAARQQNLLPR
YTWGKDFNINICKRGNNFEVTLATKVKKKKEKNYKVVLGYAANIVRKNTY
AAIEAHANGDGVIDYNDLPVKPIESGFVTVESQVRDKSYDQLSYNGVKLL
YCKPHVESRRSFLEKYRNGTMKDNRGNNIQIDFMKDFEAIADDETSLYYF
NMKYCKLLQSSIRNHSSQAKEYREEIFELLRDGKLSVLKLSSLSNLSFVM
FKVAKSLIGTYFGHLLKKPAPPITDEDKQKADPEMFALRLALEEKRLNKV
KSKKEVIANKIVAKALELRDKYGPVLIKGENISDTTKKGKKSSTNSFLMD
WLARGVANKVKEMVMMHQGLEFVEVNPNFTSHQDPFVHKNPENTFRARYS
RCTPSELTEKNRKEILSFLSDKPSKRPTNAYYNEGAMAFLATYGLKKNDV
LGVSLEKFKQIMANILHQRSEDQLLFPSRGGMFYLATYKLDADATSVNWN
GKQFWVCNADLVAAYNVGLVDIQKDFK

3D structure

PDB

7d2l Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1.

Chain

Resolution

2.75 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	R12 K13 A14 T16 R22 K463 Q464 K465 N467 P468 K472 Y473 H497 N498 R503 D507 Y509 W511 H528 S532 T534 R535 K560 K567 L570 I575 R579 G584 L585 K587 V588 K590 R591 R594 T627 S688 Q689 Y695 Q697 Y700 V703 Y707 Y754 Q765 R769 S797 S812 G815 T816 H820 K823 K859 N862 K863 S866 E869 N873 T900 K902 S906 N909 M913 K923 M927	R6 K7 A8 T10 R16 K457 Q458 K459 N461 P462 K466 Y467 H491 N492 R497 D501 Y503 W505 H522 S526 T528 R529 K554 K561 L564 I569 R573 G578 L579 K581 V582 K584 R585 R588 T621 S682 Q683 Y689 Q691 Y694 V697 Y701 Y748 Q759 R763 S791 S806 G809 T810 H814 K817 K845 N848 K849 S852 E855 N859 T886 K888 S892 N895 M899 K909 M913
BS02	dna	A	R12 T168 R225 R228 R233 K234 G235 A236 K313 G314 T317 W361 H367 K426 T427 L429 N477 N481 S482 K483 N614 K631 D729 T838 D839 M913 L916 R918 G919	R6 T162 R219 R222 R227 K228 G229 A230 K307 G308 T311 W355 H361 K420 T421 L423 N471 N475 S476 K477 N608 K625 D723 T824 D825 M899 L902 R904 G905
BS03	dna	A	H170 Y171 S174 G178 G180 A181 K182 N183 K188 K234 G235 A236 P238 S239 K269 N649 I650 V651 R652 I896 F911 W915 P941 N942 F943 T944 S945 H946 R962 R990 P991 T992	H164 Y165 S168 G172 G174 A175 K176 N177 K182 K228 G229 A230 P232 S233 K263 N643 I644 V645 R646 I882 F897 W901 P927 N928 F929 T930 S931 H932 R948 R976 P977 T978

External links

PDB	RCSB:7d2l, PDBe:7d2l, PDBj:7d2l
PDBsum	7d2l
PubMed	34108490

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