Structure of PDB 7d0p Chain A

Receptor sequence

>7d0pA (length=276) Species: 9606 (Homo sapiens)

MIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHM
AKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLY
YDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQG
YGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQ
GKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWI
AKEAKRSNSNKTMDPSCLKWTPPKGT

3D structure

• PDB: 7d0p HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C474 E508
• Catalytic site (residue number reindexed from 1): C139 E173
• Enzyme Commision number: 2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	F534 K537 E538 I539 S540 I541 K542 P552 Y567 H572 L573 V574 L575 K576	F199 K202 E203 I204 S205 I206 K207 P217 Y232 H237 L238 V239 L240 K241
BS02	1VU	A	F428 L429 S473 C474 I475 L476 T477 M482 R483 G485 G487 K488 E508 S512 L514 I517 S518 S521	F93 L94 S138 C139 I140 L141 T142 M147 R148 G150 G152 K153 E173 S177 L179 I182 S183 S186
BS03	ZN	A	C368 C371 H384 C388	C33 C36 H49 C53

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:7d0p, PDBe:7d0p, PDBj:7d0p
• PDBsum: 7d0p
• PubMed: 34259319
• UniProt: O95251|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)