Structure of PDB 7cym Chain A

Receptor sequence

>7cymA (length=417) Species: 9606 (Homo sapiens) [Search protein sequence]

KFSGPLKPMTFSIYEGQEPSQIIFQFKANPPAVTFELTGETDNIFVIERE
GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRPT
FLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMIN
NVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGGQSENSFS
DTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVD
KEKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLE
IHVKVKDINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANS
FLNYRIVEQTPKLPMDGLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVS
DKDFKTLCFVQINVIDE

3D structure

PDB

7cym Mechanism of dimerization and structural features of human LI-cadherin.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	N120 N122 D152 D154 N160 D215	N95 N97 D127 D129 N135 D190
BS02	CA	A	E40 E87 D118 I119 D121 D154	E15 E62 D93 I94 D96 D129
BS03	CA	A	E40 D85 E87 D121	E15 D60 E62 D96
BS04	CA	A	E249 D299 E301 D335	E224 D274 E276 D310
BS05	CA	A	E249 E301 D332 I333 D335 D368	E224 E276 D307 I308 D310 D343
BS06	CA	A	N334 N336 D366 D368 N374 D426	N309 N311 D341 D343 N349 D401

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7cym, PDBe:7cym, PDBj:7cym
PDBsum	7cym
PubMed	34364873
UniProt	Q12864\|CAD17_HUMAN Cadherin-17 (Gene Name=CDH17)

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