Structure of PDB 7cxy Chain A

Receptor sequence
>7cxyA (length=214) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
DTVPQYLKQSHERIFENNRAWVATKMKDDPAFFEKLSAGQTPEYLYIGCS
DSRVPANEIMGLEAGEVFVHRNIANLVPNTDLNVMSVINYAVRHLQVKHI
VVCGHYHCGGVKAALTPSDLGLLNPWLRNVRDVYRLHEQELDGIQDATAR
ARRLVELNVIESCRNVIKTAAVQQSFHERQFPVVHGWIFDVETGLLRDLE
IDFEETLRDIKKIY
3D structure
PDB7cxy Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C57 D59 H113 C116 C49 D51 H105 C108
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0015976 carbon utilization
GO:0034599 cellular response to oxidative stress
GO:0071244 cellular response to carbon dioxide
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cxy, PDBe:7cxy, PDBj:7cxy
PDBsum7cxy
PubMed33545350
UniProtA4DA32

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