Structure of PDB 7cuq Chain A

Receptor sequence

>7cuqA (length=659) Species: 562 (Escherichia coli) [Search protein sequence]

MFGKLSLDAVPFHEPIVMVTIAGIILGGLALVGLITYFGKWTYLWKEWLT
SVDHKRLGIMYIIVAIVMLLRGFADAIMMRSQQALASAGEAGFLPPHHYD
QIFTAHGVIMIFFVAMPFVIGLMNLVVPLQIGARDVAFPFLNNLSFWFTV
VGVILVNVSLGVGEFAQTGWLAYPPLSGIEYSPGVGVDYWIWSLQLSGIG
TTLTGINFFVTILKMRAPGMTMFKMPVFTWASLCANVLIIASFPILTVTV
ALLTLDRYLGTHFFTNDMGGNMMMYINLIWAWGHPEVYILILPVFGVFSE
IAATFSRKRLFGYTSLVWATVCITVLSFIVWLHHFFTMGAGANVNAFFGI
TTMIIAIPTGVKIFNWLFTMYQGRIVFHSAMLWTIGFIVTFSVGGMTGVL
LAVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYWWPKAFGFKLNE
TWGKRAFWFWIIGFFVAFMPLYALGFMGMTRRLSQQIDPQFHTMLMIAAS
GAVLIALGILCLVIQMYVSIRDRDQNRDLTGDPWGGRTLEWATSSPPPFY
NFAVVPHVHERDAFWEMKEKGEAYKKPDHYEEIHMPKNSGAGIVIAAFST
IFGFAMIWHIWWLAIVGFAGMIITWIVKSFDEDVDYYVPVAEIEKLENQH
FDEITKAGL

3D structure

PDB

7cuq Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site.

Chain

Resolution

2.64 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

7.1.1.3: ubiquinol oxidase (H(+)-transporting).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	F73 R80 F103 H106 M110 I111 W170 F420 H421 F468 R481 R482 I505	F73 R80 F103 H106 M110 I111 W170 F420 H421 F468 R481 R482 I505
BS02	HEO	A	W280 V287 H333 H334 T352 A356 G360 I363 F391 S392 G395 G398 L401 D407 L410 H411 L416 H419 F420 V423 R481	W280 V287 H333 H334 T352 A356 G360 I363 F391 S392 G395 G398 L401 D407 L410 H411 L416 H419 F420 V423 R481
BS03	CU	A	H284 H333 H334	H284 H333 H334
BS04	UQ8	A	T20 R71 A74 H98 Q101 A105 N157 L160	T20 R71 A74 H98 Q101 A105 N157 L160

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0009055	electron transfer activity
GO:0009486	cytochrome bo3 ubiquinol oxidase activity
GO:0015078	proton transmembrane transporter activity
GO:0015453	oxidoreduction-driven active transmembrane transporter activity
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0048039	ubiquinone binding

	Biological Process
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport
GO:0019646	aerobic electron transport chain
GO:0022904	respiratory electron transport chain
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0009319	cytochrome o ubiquinol oxidase complex
GO:0016020	membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7cuq, PDBe:7cuq, PDBj:7cuq
PDBsum	7cuq
PubMed	34417297
UniProt	P0ABI8\|CYOB_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 1 (Gene Name=cyoB)

[Back to BioLiP]