Structure of PDB 7cru Chain A

Receptor sequence

>7cruA (length=428) Species: 9606 (Homo sapiens) [Search protein sequence]

WSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFV
SFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPH
AHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGY
LRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAI
SYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTD
EQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVN
HGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPL
MNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEA
LQNHENESVYKASLSLIEKYFSEGYTFQ

3D structure

PDB

7cru Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	S105 W142 N146 S149 G150 Q181 W184 N188 D192 N228 W231 R238 D270 W273 R315 V321 T328 K348 N350 W357 N361 E396 W399 T402 S406 D442	S30 W67 N71 S74 G75 Q106 W109 N113 D117 N153 W156 R163 D195 W198 R240 V246 T253 K273 N275 W282 N286 E321 W324 T327 S331 D367

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7cru, PDBe:7cru, PDBj:7cru
PDBsum	7cru
PubMed	34689235
UniProt	P52292\|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)

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