Structure of PDB 7cqm Chain A

Receptor sequence

>7cqmA (length=200) Species: 224324 (Aquifex aeolicus VF5)

GSALFLVIFAYLLGSITFGEVIAKLKGVDLRNVGSGNVGATNVTRALGKK
YGVLVFFLDFLKGFIPALIAVKSFGIDSWVLTFTGLASVLGHMYPVFFGF
KGGKGVATALGVVFAVSPSVALFSFLVWLGIFLWKRYVSLASITATISAF
LFLFVAGYPVNVLFMAIVIGALIIYRHRENINRLLTGREHRFGTLEVLFQ

3D structure

• PDB: 7cqm Selenourea for experimental phasing of membrane protein crystals grown in lipid cubic phase
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.275: acyl phosphate:glycerol-3-phosphate acyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SEY	A	F74 S78	F74 S78
BS02	SEY	A	T17 E20 V21 F100	T17 E20 V21 F100
BS03	SEY	A	H190 R191 F192	H190 R191 F192
BS04	SEY	A	G193 T194	G193 T194
BS05	SEY	A	N32 V33 G34	N32 V33 G34
BS06	SEY	A	Y94 P95 F100	Y94 P95 F100
BS07	79M	A	K104 V113 W128 V138 S142 I169 H177	K104 V113 W128 V138 S142 I169 H177
BS08	79M	A	T41 T44 L110 F125	T41 T44 L110 F125
BS09	79M	A	F150 G170 E179	F150 G170 E179
BS10	79M	A	F57 F60 V71 K72 F114 A115 V116 P118	F57 F60 V71 K72 F114 A115 V116 P118
BS11	79M	A	F123 F152 Y158	F123 F152 Y158
BS12	79M	A	F154 V160 F164 I167	F154 V160 F164 I167
BS13	79M	A	P118 L122	P118 L122
BS14	SEY	A	F154 G157 Y158	F154 G157 Y158
BS15	79M	A	G130 I131	G130 I131
BS16	79M	A	I131 W134	I131 W134

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0043772 acyl-phosphate glycerol-3-phosphate acyltransferase activity

Biological Process

• GO:0006644 phospholipid metabolic process
• GO:0008654 phospholipid biosynthetic process

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:7cqm, PDBe:7cqm, PDBj:7cqm
• PDBsum: 7cqm
• UniProt: O66905|PLSY_AQUAE Glycerol-3-phosphate acyltransferase (Gene Name=plsY)