Structure of PDB 7cqe Chain A

Receptor sequence
>7cqeA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
EDVVIDRNLLILGKILGEGGSVMEGNLKQEDGTSLKVAVKTMKREIEEFL
SEAACMKDFSHPNVIRLLGVCIEMIPKPMVILPFMKYGDLHTYLLYSRLE
TGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCV
ADFGPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHE
MYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL
ESL
3D structure
PDB7cqe Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development.
ChainA
Resolution2.69 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 R727 N728 D741
Catalytic site (residue number reindexed from 1) D134 R138 N139 D152
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YDJ A A617 F673 M674 K675 R727 N728 M730 D741 A38 F84 M85 K86 R138 N139 M141 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7cqe, PDBe:7cqe, PDBj:7cqe
PDBsum7cqe
PubMed33114206
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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