Structure of PDB 7cmd Chain A

Receptor sequence
>7cmdA (length=306) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
AEVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNS
HEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVN
GLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCA
LILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTL
KGVEAVMYMGTLSYEQFKKGVTKYLVQQESPFVMMSAPPAQYELKHGTFT
CASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENS
YTTTIK
3D structure
PDB7cmd Crystal structure of SARS-CoV-2 papain-like protease.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTT A G163 D164 P248 Y264 Y268 Q269 G164 D165 P239 Y255 Y259 Q260 BindingDB: IC50=1610nM,Kd=2700nM,EC50=27600nM
BS02 ZN A C189 C192 C190 C193
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7cmd, PDBe:7cmd, PDBj:7cmd
PDBsum7cmd
PubMed32895623
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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