Structure of PDB 7cmc Chain A

Receptor sequence
>7cmcA (length=312) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
EGVEVKGPWLDDAQSLEEVVSYYYRIGFQATHLGRAIEIWRKVEEKRERG
EEIRVFLGYTSNIISSGLREIIAWLVKEKKVDVIVTTAGGVEEDFIKSLK
PFILGDWAELRKKGVNRIGNIFVPNDRYIEFEKYMIPFFERVLKIEEKLS
RPLTASEFIYEMGRYMDEKLGKEKEKSVIYWAYKNNIPIFCPAITDGSIG
DMLYFFKEERRDSRLIIDIANDIVKLNNLAITAKETASIILGGSLPKHAI
INANLFRGGTDYAIYISTAVPWDGSLSGAPPREGVSWADYVEVWGDATLI
FPILVWMVMKAR
3D structure
PDB7cmc Flexible NAD+Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E107 H266
Catalytic site (residue number reindexed from 1) E93 H248
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A T74 S75 N76 T101 A102 G103 E107 I136 D214 G260 G261 S262 S285 T286 A287 D320 A321 T60 S61 N62 T87 A88 G89 E93 I118 D196 G242 G243 S244 S267 T268 A269 D296 A297
BS02 NAD A S262 H266 S244 H248
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
Biological Process
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cmc, PDBe:7cmc, PDBj:7cmc
PDBsum7cmc
PubMed32752130
UniProtO50105|DHYS_PYRHO Probable deoxyhypusine synthase (Gene Name=dys)

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