Structure of PDB 7ckm Chain A

Receptor sequence
>7ckmA (length=1603) [Search protein sequence]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTTQEELSLMYEALTEEQVESFNEIKHDVQVALAKMADV
SLHEVKDFDPDVLPPEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLK
NLTTSSYVDEEYFMCFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSI
SSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKY
TCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQML
ELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFF
HQTMQLNGQIPSHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDV
IPVSYTSSDDQITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGT
FVAEFKSRFFVMGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCI
ANGVSTKIVTRISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRL
QRKIEAIFHDDKETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEAL
TGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQ
SKLSRQSSVASGFIGFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICAL
KPKIIYCNNSLNKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNN
QNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVS
RTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAH
IRQ
3D structure
PDB7ckm Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals
ChainA
Resolution3.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D1188 D1330 E1381 D1030 D1160 E1204
BS02 ZN A C284 C470 H472 C272 C437 H439
BS03 ZN A C1652 C1655 C1445 C1448
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ckm, PDBe:7ckm, PDBj:7ckm
PDBsum7ckm
PubMed
UniProtQ6IVU0

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