Structure of PDB 7ckf Chain A

Receptor sequence
>7ckfA (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
SDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNK
LAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKA
DNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKAPDL
VWTLRDFCLGLEIDGQLVTPDEYLENSLRPFPKKKCFIFDLPAHQKKLAQ
LETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLT
YVNAIS
3D structure
PDB7ckf Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
ChainA
Resolution2.284 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S52 T75 S45 T68
BS02 GDP A R48 T49 G50 K51 S52 Y53 V67 A68 S69 R181 D182 P239 L245 L248 R41 T42 G43 K44 S45 Y46 V60 A61 S62 R155 D156 P192 L198 L201
BS03 AF3 A Y47 R48 K51 T75 G100 Y40 R41 K44 T68 G93
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7ckf, PDBe:7ckf, PDBj:7ckf
PDBsum7ckf
PubMed33876762
UniProtQ96PP8|GBP5_HUMAN Guanylate-binding protein 5 (Gene Name=GBP5)

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