Structure of PDB 7cgq Chain A

Receptor sequence

>7cgqA (length=306) Species: 192 (Azospirillum brasilense)

QVSLGVVGIGKIARDQHLPAIDAEPGFKLTACASRHAEVTGVRNYRDLRA
LLAAERELDAVSLCAPPQVRYAQARAALEAGKHVMLEKPPGATLGEVAVL
EALARERGLTLFATWHSRCASAVEPAREWLATRAIRAVQVRWKADVRRWH
PGQQWIWEPGGLGVFDPGINALSIVTRILPRELVLREATLIVPSDVQTPI
AAELDCADTDGVPVRAEFDWRHGPVEQWEIAVDTADGVLAISRGGAQLSI
AGEPVELGPEREYPALYAHFHALIARGESDVDVRPLRLVADAFLFGRRVQ
TDAFGR

3D structure

• PDB: 7cgq Crystal structure of bacterial L-arabinose 1-dehydrogenase in complex with L-arabinose and NADP+
• Chain: A
• Resolution: 2.208 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.120: galactose 1-dehydrogenase (NADP(+)).
  1.1.1.376: L-arabinose 1-dehydrogenase [NAD(P)(+)].
  1.1.1.48: D-galactose 1-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	G13 K14 I15 S37 R38 H39 C67 A68 P69 V72 E90 K91 H119 Q156 W158 D169 Y266	G10 K11 I12 S34 R35 H36 C64 A65 P66 V69 E87 K88 H116 Q153 W155 D166 Y263
BS02	ARA	A	K91 H119 H153 P170 N173	K88 H116 H150 P167 N170

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0019151 galactose 1-dehydrogenase activity
• GO:0044103 L-arabinose 1-dehydrogenase (NADP+) activity
• GO:0047910 galactose 1-dehydrogenase (NADP+) activity
• GO:0050022 L-arabinose 1-dehydrogenase (NAD+) activity
• GO:0070401 NADP+ binding
• GO:0070403 NAD+ binding

Biological Process

• GO:0019568 arabinose catabolic process
• GO:0019570 L-arabinose catabolic process to 2-oxoglutarate
• GO:0019572 L-arabinose catabolic process

External links

• PDB: RCSB:7cgq, PDBe:7cgq, PDBj:7cgq
• PDBsum: 7cgq
• UniProt: Q53TZ2|ARAA_AZOBR L-arabinose 1-dehydrogenase (NAD(P)(+)) (Gene Name=araA)