Structure of PDB 7ceu Chain A

Receptor sequence
>7ceuA (length=362) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
VQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEA
LDKLYKGINARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTV
AEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVREAITEKTALVSVM
WANNETGLIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANADFLS
FSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSGTLNVPYIVGMG
EAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLV
SVRGIEGEAMLWDLNRSNIAASTGSAHTAIRLSLSRFNTEAEIDKTIEVF
SQAAVRLRNISS
3D structure
PDB7ceu Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7TS A N10 C72 A73 T74 H104 N155 D180 V182 S203 H205 K206 R354 N9 C71 A72 T73 H103 N154 D179 V181 S202 H204 K205 R331
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006534 cysteine metabolic process
GO:0016226 iron-sulfur cluster assembly
GO:0044571 [2Fe-2S] cluster assembly
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ceu, PDBe:7ceu, PDBj:7ceu
PDBsum7ceu
PubMed35395703
UniProtO25008|ISCS_HELPY Cysteine desulfurase IscS (Gene Name=iscS)

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