Structure of PDB 7cep Chain A

Receptor sequence
>7cepA (length=414) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence]
GHMNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKYYNQY
NSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNM
VALSYARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDG
TISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVD
GAQSTPHMKIDVQDLDCDFFALSSHKMCGPTGVGVLYGKKALLENMEPAE
FGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDE
ISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTFNLDDVHPHDVATVL
DAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLVEALQKT
KEYFTNVFVDLEHH
3D structure
PDB7cep Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7TS A A28 A29 T92 T93 H121 N173 D198 A200 S221 H223 K224 R376 A30 A31 T94 T95 H123 N175 D200 A202 S223 H225 K226 R378
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
Biological Process
GO:0006534 cysteine metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7cep, PDBe:7cep, PDBj:7cep
PDBsum7cep
PubMed35395703
UniProtO32164|SUFS_BACSU Cysteine desulfurase SufS (Gene Name=sufS)

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