Structure of PDB 7ccz Chain A

Receptor sequence
>7cczA (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMKSLFTKELEHAL
EKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLE
TLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSA
IILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLV
GVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSL
DGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLG
ISLANLLLSKGAKNILDVARQLN
3D structure
PDB7ccz Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.
ChainA
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K98 D99 R149 R150 R167 R173 C261
Catalytic site (residue number reindexed from 1) K63 D64 R114 R115 R132 R138 C226
Enzyme Commision number 2.5.1.61: hydroxymethylbilane synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7J8 A S96 K98 D99 P101 T102 S146 S147 R149 R150 R173 L188 A189 V215 Q217 L254 C261 S61 K63 D64 P66 T67 S111 S112 R114 R115 R138 L153 A154 V180 Q182 L219 C226
Gene Ontology
Molecular Function
GO:0004418 hydroxymethylbilane synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006784 heme A biosynthetic process
GO:0006785 heme B biosynthetic process
GO:0018160 peptidyl-pyrromethane cofactor linkage
GO:0033014 tetrapyrrole biosynthetic process
GO:0048034 heme O biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ccz, PDBe:7ccz, PDBj:7ccz
PDBsum7ccz
PubMed33600566
UniProtP08397|HEM3_HUMAN Porphobilinogen deaminase (Gene Name=HMBS)

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