Structure of PDB 7cca Chain A

Receptor sequence
>7ccaA (length=289) Species: 654913 (Shrimp white spot syndrome virus (isolate Tongan)) [Search protein sequence]
MEGEHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLT
TKKIFWRGVVEELLWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYD
RAEGDLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDDR
RMIMTAWNPMDLHLMALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVPF
NIASYSLLTHLMASMVGLKPGEFILTLGDAHIYNTHIEVLKKQLCRVPRP
FPKLRILMAPEKIEDFTIDMFYLEGYQPHSGNLQMKMAV
3D structure
PDB7cca Structure analysis of thymidylate synthase from white spot syndrome virus reveals WSSV-specific structural elements.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E62 W84 Y110 C170 R190 D193
Catalytic site (residue number reindexed from 1) E62 W84 Y110 C170 R190 D193
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A R24 C170 H171 R190 S191 D193 N201 H231 Y233 R24 C170 H171 R190 S191 D193 N201 H231 Y233
BS02 MTX A H82 I83 F200 Y233 K286 H82 I83 F200 Y233 K286
BS03 UMP A R150 R151 R150 R151
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7cca, PDBe:7cca, PDBj:7cca
PDBsum7cca
PubMed33197475
UniProtQ77J90

[Back to BioLiP]