Structure of PDB 7cb7 Chain A

Receptor sequence
>7cb7A (length=307) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
GSGGGSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICT
SEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTAN
PKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSC
GSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAG
TDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQD
HVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFD
VVRQCSG
3D structure
PDB7cb7 Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug.
ChainA
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K36 A M49 F140 N142 G143 C145 H163 H164 M165 E166 D187 Q189 M54 F145 N147 G148 C150 H168 H169 M170 E171 D192 Q194 BindingDB: IC50=190nM
BS02 B1S A H41 M49 F140 N142 C145 H163 H164 M165 E166 Q189 H46 M54 F145 N147 C150 H168 H169 M170 E171 Q194
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7cb7, PDBe:7cb7, PDBj:7cb7
PDBsum7cb7
PubMed32905393
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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