Structure of PDB 7cb5 Chain A

Receptor sequence
>7cb5A (length=466) Species: 426430 (Staphylococcus aureus subsp. aureus str. Newman) [Search protein sequence]
MTQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNI
HPTYSLEEFVNSLEKPRKILLMVQAGKATDATIDSLLPLLDDGDILIDGG
NTNYQDTIRRNKALAQSAINFIGMGVSGGEIGALTGPSLMPGGQEEAYNK
VADILDAIAAKAKDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESY
AMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMKLDENKEALVE
KILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASK
ELNGPKASFDGDKKDFLEKIRKALYMSKICSYAQGFAQMRKASEDNEWNL
KLGDLAMIWREGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQ
DALRDVVATGVQNGVPTPGFSSSINYYDSYRAADLPANLIQAQRDYFGAH
TYERKDKEGVFHTQWI
3D structure
PDB7cb5 Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance.
ChainA
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.44: phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6PG A S127 K182 N186 Y190 K259 I364 S127 K182 N186 Y190 K259 I364
BS02 6PG A R444 H450 R444 H450
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0016054 organic acid catabolic process
GO:0019521 D-gluconate metabolic process
GO:0046177 D-gluconate catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cb5, PDBe:7cb5, PDBj:7cb5
PDBsum7cb5
PubMed34099682
UniProtA0A0H3KGN1

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