Structure of PDB 7c8k Chain A

Receptor sequence
>7c8kA (length=596) Species: 196889 (Rhinolophus macrotis) [Search protein sequence]
STTEDEAKKFLDKFNSKAEDLSYESSLASWDYNTNISDENVQKMDEAGAK
WSAFYEEQSKLAKNYPLEEIQNDTVKRQLQILQQSGSPVLSEDKSKRLNS
ILNAMSTIYSTGKVCKPNNPQECLLLEPGLDNIMGTSKDYNERLWAWEGW
RAEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEESSGPGYS
RDQLMKDVDRIFTEIKPLYEHLHAYVRAKLMDTYPLHISPTGCLPAHLLG
DMWGRFWTNLYPLTVPFGQKPNIDVTDAMLNQGWDANRIFKEAEKFFVSV
SLPKMTEGFWNKSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMED
FLTAHHEMGHIQYDMAYASQPYLLRNGANEGFHEAVGEVMSLSVATPKHL
KTMGLLSPDFREDDETEINFLLKQALNIVGTLPFTYMLEKWRWMVFKGEI
PKEEWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTR
TIFEFQFHEALCRIAQHNGPLHKCDISNSTDAGKKLHQMLSVGKSQAWTK
TLEDIVDSRNMDVGPLLRYFKPLYTWLQEQNRKSYVGWNTDWSPYA
3D structure
PDB7c8k Cross-species recognition of SARS-CoV-2 to bat ACE2.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H345 P346 H374 E375 H378 E402 H505 Y515
Catalytic site (residue number reindexed from 1) H327 P328 H356 E357 H360 E384 H487 Y497
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H374 H378 E402 H356 H360 E384
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c8k, PDBe:7c8k, PDBj:7c8k
PDBsum7c8k
PubMed33335073
UniProtE2DHI3

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