Structure of PDB 7c8j Chain A

Receptor sequence
>7c8jA (length=707) Species: 196889 (Rhinolophus macrotis) [Search protein sequence]
TTEDEAKKFLDKFNSKAEDLSYESSLASWDYNTNISDENVQKMDEAGAKW
SAFYEEQSKLAKNYPLEEIQNDTVKRQLQILQQSGSPVLSEDKSKRLNSI
LNAMSTIYSTGKVCKPNNPQECLLLEPGLDNIMGTSKDYNERLWAWEGWR
AEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEESSGPGYSR
DQLMKDVDRIFTEIKPLYEHLHAYVRAKLMDTYPLHISPTGCLPAHLLGD
MWGRFWTNLYPLTVPFGQKPNIDVTDAMLNQGWDANRIFKEAEKFFVSVS
LPKMTEGFWNKSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMEDF
LTAHHEMGHIQYDMAYASQPYLLRNGANEGFHEAVGEVMSLSVATPKHLK
TMGLLSPDFREDDETEINFLLKQALNIVGTLPFTYMLEKWRWMVFKGEIP
KEEWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRT
IFEFQFHEALCRIAQHNGPLHKCDISNSTDAGKKLHQMLSVGKSQAWTKT
LEDIVDSRNMDVGPLLRYFKPLYTWLQEQNRKSYVGWNTDWSPYADQSIK
VWISLKSALGEKAYEWNDNEMYLFRSSVAYAMREYFLKTKNQTILFGDEN
VWVSNLKPRISFNFHVTSPGNVSDIIPRPEVEGAIRMSRSRINDAFRLDD
NSLEFLG
3D structure
PDB7c8j Cross-species recognition of SARS-CoV-2 to bat ACE2.
ChainA
Resolution3.18 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H345 P346 H374 E375 H378 E402 H505 Y515
Catalytic site (residue number reindexed from 1) H326 P327 H355 E356 H359 E383 H486 Y496
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H374 H378 E402 H355 H359 E383
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c8j, PDBe:7c8j, PDBj:7c8j
PDBsum7c8j
PubMed33335073
UniProtE2DHI3

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