Structure of PDB 7c7s Chain A

Receptor sequence
>7c7sA (length=685) Species: 9606 (Homo sapiens) [Search protein sequence]
HSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKL
IHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLI
VLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQ
QTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIV
GLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVD
EMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGG
FQEAPLAYDAIWALALALNKTSGVRLEDFNYNNQTITDQIYRAMNSSSFE
GVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWI
GGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHV
RYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWL
LGLGFSLGYGSMFTKIWWVHTVFTKLEPWKLYATVGLLVGMDVLTLAIWQ
IVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGL
LLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQ
QDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRG
3D structure
PDB7c7s Cryo-EM structures of inactive and active GABABreceptor.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2BV A W182 C246 S247 G268 S269 S270 H287 W395 E466 W19 C83 S84 G105 S106 S107 H124 W232 E303
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004965 G protein-coupled GABA receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c7s, PDBe:7c7s, PDBj:7c7s
PDBsum7c7s
PubMed32494023
UniProtQ9UBS5|GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (Gene Name=GABBR1)

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