Structure of PDB 7c60 Chain A

Receptor sequence
>7c60A (length=297) Species: 10090 (Mus musculus) [Search protein sequence]
VPRGSHMVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLA
GCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRI
GVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVA
VLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLH
NCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKI
YVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
3D structure
PDB7c60 Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NF3 A V370 G371 V54 G55 MOAD: Kd=27nM
BS02 NF3 A Y525 Q530 S555 Y572 Y209 Q214 S239 Y256 MOAD: Kd=27nM
External links
PDB RCSB:7c60, PDBe:7c60, PDBj:7c60
PDBsum7c60
PubMed32672401
UniProtQ9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)

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