Structure of PDB 7c5d Chain A

Receptor sequence
>7c5dA (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
RLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHT
VSRLLRVMQCLSRIEEGENLDCSFDMLTPLESAINVLEMIKTEFTLTEAV
VESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDTTQKLRNDLLNIIR
EKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKAL
3D structure
PDB7c5d Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly.
ChainA
Resolution2.151 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R80 Q84 L87 E94 S98 L101 R102 M104 Q105 R109 D117 C118 S119 F120 R34 Q38 L41 E48 S52 L55 R56 M58 Q59 R63 D71 C72 S73 F74
Gene Ontology
Molecular Function
GO:0042162 telomeric DNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0031848 protection from non-homologous end joining at telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c5d, PDBe:7c5d, PDBj:7c5d
PDBsum7c5d
PubMed33203878
UniProtQ15554|TERF2_HUMAN Telomeric repeat-binding factor 2 (Gene Name=TERF2)

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