Structure of PDB 7c4b Chain A

Receptor sequence
>7c4bA (length=297) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
SSSSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLG
RISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRR
DVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLT
RQEGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGN
KDVPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPG
GGCHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLL
3D structure
PDB7c4b Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
ChainA
Resolution2.101 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C297 C300 H305 C310 C253 C256 H261 C266
BS02 ZN A C320 C323 H328 C333 C276 C279 H284 C289
BS03 MN A D80 D145 D36 D101
BS04 MN A D80 E82 D230 D36 E38 D186
BS05 U A H305 E309 C310 F311 H261 E265 C266 F267
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:1990923 PET complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c4b, PDBe:7c4b, PDBj:7c4b
PDBsum7c4b
PubMed33332555
UniProtQ38DE2

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