Structure of PDB 7c45 Chain A

Receptor sequence

>7c45A (length=295) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]

SATSSSSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAK
QLGRISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFD
CRRDVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVA
GLTRDSAVQTAMTLRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGNKD
VPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPGGG
CHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLL

3D structure

PDB

7c45 Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.

Chain

Resolution

1.769 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	E82 A83 L93 D141 Q164 R179 S181 G182 Y185 R195 M206 P279 A280 H305 E309 C310 F311 G327 H328 N332 C333 F334 K335	E41 A42 L52 D100 Q123 R138 S140 G141 Y144 R154 M162 P233 A234 H259 E263 C264 F265 G281 H282 N286 C287 F288 K289
BS02	ZN	A	C297 C300 H305 C310	C251 C254 H259 C264
BS03	ZN	A	C320 C323 H328 C333	C274 C277 H282 C287
BS04	CA	A	D80 E82 D230	D39 E41 D184

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0008270	zinc ion binding
GO:0008408	3'-5' exonuclease activity

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7c45, PDBe:7c45, PDBj:7c45
PDBsum	7c45
PubMed	33332555
UniProt	Q38DE2

[Back to BioLiP]