Structure of PDB 7c44 Chain A

Receptor sequence
>7c44A (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
DLENLYFQGSQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMV
KQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVT
3D structure
PDB7c44 Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NUT A M52 G56 I59 M60 Q70 V91 L97 M41 G45 I48 M49 Q59 V80 L86 BindingDB: IC50=>10000nM
BS02 O4B A P31 K34 P20 K23
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7c44, PDBe:7c44, PDBj:7c44
PDBsum7c44
PubMed
UniProtO15151|MDM4_HUMAN Protein Mdm4 (Gene Name=MDM4)

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