Structure of PDB 7c3y Chain A

Receptor sequence
>7c3yA (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
DLENLYFQGSQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMV
KQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVT
3D structure
PDB7c3y Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a
ChainA
Resolution1.632 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NUT A M52 G56 I59 M60 Q70 V91 P94 L97 M41 G45 I48 M49 Q59 V80 P83 L86 BindingDB: IC50=>10000nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7c3y, PDBe:7c3y, PDBj:7c3y
PDBsum7c3y
PubMed
UniProtO15151|MDM4_HUMAN Protein Mdm4 (Gene Name=MDM4)

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