Structure of PDB 7bz0 Chain A

Receptor sequence

>7bz0A (length=496) Species: 29497 (Vibrio splendidus)

SISEIDRSYLLSSDRLTEVDGNTLDVASEEQVAALKAQFENLKDGDEVVI
PNGKYANLGQVTITANDVTIRAEQAGAAWLTGLIQFELKGDDITLDGLVF
TEGGPNERFGAVRMMGNGNTLQNSTFYYFNHDYTYEPDERRSEYPKYLWV
SLWGKDGKVINNRFEGKQKRGTLIGVQKDDTPDNHLIANNIFMDQKPNQF
NEFDIKEAIRYNGNSWEAIRIGDSKSSQWDSSSKFVNNLMIDMDGERELI
SIASGDNTISGNTIFQSAALISLRHGKGNTVENNMILGNEKRLTGGIRIY
DEDHVIRNNYIANTRGRDGEGNADLRGGIVINTGIIDVANGEQLDQSVKG
KELNKQWTPKNITIENNSLVDTEWGIVYGNQSHRVSLFNNAEVEGIYAGV
DIAFKHNVVDNSQTPEFVSVRATHDFPLVGATYTDETYVGQVTDSELIES
YSVELPKVTVENGLNAYQGEGADVSKLSVVTAETAGPDYVLENTTK

3D structure

• PDB: 7bz0 Structural insights into the substrate-binding cleft of AlyF reveal the first long-chain alginate-binding mode.
• Chain: A
• Resolution: 1.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LGU	A	R127 K165 R239 D242	R108 K146 R220 D223
BS02	LGU	A	K165 S234 S243	K146 S215 S224
BS03	LGU	A	N233 E267 R293 H294 N375	N214 E248 R274 H275 N354
BS04	LGU	A	R293 R317 Y319 L408	R274 R298 Y300 L387
BS05	LGU	A	R229 R266 D345	R210 R247 D324
BS06	LGU	A	R266 R336 D345 R405	R247 R317 D324 R384
BS07	CA	A	N233 E236 E265 E267	N214 E217 E246 E248

External links

• PDB: RCSB:7bz0, PDBe:7bz0, PDBj:7bz0
• PDBsum: 7bz0
• PubMed: 33645537