Structure of PDB 7by6 Chain A

Receptor sequence
>7by6A (length=299) Species: 5855 (Plasmodium vivax) [Search protein sequence]
LTYLLIKNEEYKKYQVKKYNFFSSGKKMNKGNIHLLIRQMRTFKDVFVSL
GFEEMNTHNYVESSFWCFDALYIPQQHPSRDLQDTFFIKVPEMCQEEFTD
QSYIENVKRVHSVGDYGSFGWNYQWELKSTKKNVLRTHTTANSCRALFQL
AKEYQKTGSIIPKKFFSIDRVFRNENLDSTHLAEFHQVEGLIIDRNLGLS
HLIGTLSAFYKYIGISKLRFKPTFNPYTEPSMEVYGYHEENKKWLEVGNS
GIFRPEMLRAMGFPPEVSVIAWGLSLERPTMIKYSIRNIRDLFGYRSVI
3D structure
PDB7by6 Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.
ChainA
Resolution2.997 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FB9 A I483 E516 V517 N519 S520 G543 L544 S545 R548 P549 I213 E246 V247 N249 S250 G273 L274 S275 R278 P279
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:7by6, PDBe:7by6, PDBj:7by6
PDBsum7by6
PubMed33436639
UniProtA5K9S0|SYFA_PLAVS Phenylalanine--tRNA ligase alpha subunit (Gene Name=PVX_081300)

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