Structure of PDB 7bvh Chain A

Receptor sequence
>7bvhA (length=1035) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
SNHRTARLVAIIAGLLGTLMAIATPLLPVEQTTAELNWPQNGVWQSVDAP
LIGYVATDLTVTVPCQAAAGLVGPENRNRSVLLSTVPKQAPKAIDRGLLI
ERINNDLTVIVRNTPVVSAPLEQVLSPDCRYLTFTAHADKVTGEFVGLTQ
GPDDDDPGEAVRGERSGYDFRPQIVGVFTDLSGPAPEGLQLSATIDTRYS
TSPTLLKLLAMIVGVAMTVIALGALHVLDCADGRRHKRFLPSRWWSMTPL
DGLVSAMLVWWHFVGANTADDGYILTMARVSEHAGYMANYYRWFGTPESP
FGWYYDLLALWAHVSTASVWMRFPTLLMGLACWWVISREVIPRLGAAAKH
SRAAAWTAAGLFLAFWLPLNNGLRPEPIIALGILLTWCSVERGVATSRLL
PVAVAIIIGALTLFSGPTGIAAVGALLVAIGPLKTIVAAHVSRFGYWALL
APIAAAGTVTIFLIFRDQTLAAELQASSFKSAVGPSLAWFDEHIRYSRLF
TTSPDGSVARRFAVLTLLLALAVSIAMTLRKGRIPGTALGPSRRIIGITI
ISFLAMMFTPTKWTHHFGVFAGLAGCLGALAAVAVTTTAMKSRRNRTVFG
AAVLFVTALSFATVNGWWYVSNFGVPWSNSFPEFKFGFTTMLLGLSVLAL
LVAAWFHFSGRDVSPDRPQRRWQRLLVAPLAVATWALVIFEVVSLTLGMI
NQYPAWSVGRSNLNALTGKTCGLANDVLVEQNANAGMLTPIGEPAGQALG
AVTSLGFGPNGIPSDVSADPAAGINGSRARLPYGLNPATTPVLGSWRSGT
QQPAVLRSAWYRLPDRDQAGPLLVVSAAGRFDQGEVEVQWATDEQAAANE
PGGSITFGDVGAAPAWRNLRAPLSSIPPEATQIRLVASDDDLAPQHWIAL
TPPRIPELRTLQEVVGSSDPVMLDWLVGLAFPCQRPFDHRYGVVEVPKWR
ILPDRFGAEANSPVMDYLGGGPLGITELLLRPSSVPTYLKDDWYRDWGSL
QRLTPWYPDAQPARLDLGTATRSGWWSPAPLRLSH
3D structure
PDB7bvh Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BXY A D279 Y282 W572 W627 W965 D270 Y273 W563 W618 W925
BS02 BXY A Y282 E307 Y314 Y273 E298 Y305
BS03 BGC A S490 P569 S481 P560
BS04 GLC A K489 P494 P569 K480 P485 P560
BS05 CA A D929 D931 H936 D889 D891 H896
BS06 BXY A K540 M599 K600 S601 N604 K531 M590 K591 S592 N595
BS07 BXY A F645 T649 F636 T640
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052636 arabinosyltransferase activity
Biological Process
GO:0071555 cell wall organization
GO:0071766 Actinobacterium-type cell wall biogenesis
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bvh, PDBe:7bvh, PDBj:7bvh
PDBsum7bvh
PubMed32327601
UniProtA0R612

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