Structure of PDB 7bvb Chain A

Receptor sequence
>7bvbA (length=475) Species: 233413 (Mycobacterium tuberculosis variant bovis AF2122/97) [Search protein sequence]
QLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRAR
GALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLR
PAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGE
AGTNAHHGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEA
YVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATELGIRVLRYGSVPGE
TMAATLVSWQQQGVGAVAHIRLASELGPRVMRLSVPGRHMALNALGALLA
AVQIGAPADEVLDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTE
ISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRALNAADEVF
VLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDV
IVTMGAGDVTLLGPEILTALRVRAN
3D structure
PDB7bvb Crystal structures of UDP-N-acetylmuramic acid L-alanine ligase (MurC) from Mycobacterium bovis with and without UDP-N-acetylglucosamine.
ChainA
Resolution3.191 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.3.2.8: UDP-N-acetylmuramate--L-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UD1 A G17 G20 M23 D41 H62 H81 A82 G153 E154 G13 G16 M19 D37 H58 H77 A78 G149 E150
BS02 ZN A H195 H354 H355 H191 H346 H347
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7bvb, PDBe:7bvb, PDBj:7bvb
PDBsum7bvb
PubMed33950018
UniProtP65473|MURC_MYCBO UDP-N-acetylmuramate--L-alanine ligase (Gene Name=murC)

[Back to BioLiP]