Structure of PDB 7btn Chain A

Receptor sequence
>7btnA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPR
WSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWE
DPGDNDPIDVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVD
DPDAANYNDINDVKRLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKD
KDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFKCDPDAARAI
VDALPPPCESACTVPTDVDKWFHHQ
3D structure
PDB7btn Structural and biochemical characterization of inorganic pyrophosphatase from Homo sapiens.
ChainA
Resolution2.382 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E102 D116 D118 P119 I120 D121 E100 D104 D106 P107 I108 D109
BS02 MG A D116 D118 D121 D104 D106 D109
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006796 phosphate-containing compound metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7btn, PDBe:7btn, PDBj:7btn
PDBsum7btn
PubMed33036755
UniProtQ15181|IPYR_HUMAN Inorganic pyrophosphatase (Gene Name=PPA1)

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