Structure of PDB 7bss Chain A

Receptor sequence
>7bssA (length=816) Species: 9606 (Homo sapiens) [Search protein sequence]
TRTVFVGNHPVQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIF
LVQVTVDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSTVY
IIENAKRVRKESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTA
SLDGESNCKTHYAVRDTIALCTAESIDTLRAAIECEQPQPDLYKFVGRIN
IYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYTGMETKMALNYQG
KSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSTPYNDEPWYNQ
KTQKERETLKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISW
DKDFYDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENKLQDQAAET
IEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESE
RKEDRLHELLIEYRKKLEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSIF
LQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMIL
ESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQ
YFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSL
LEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFFGTY
FLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFV
IWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIF
ISLFPEILLIVLKNVR
3D structure
PDB7bss Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF A D409 T411 G675 K795 N819 D383 T385 G416 K520 N544
BS02 MG A D409 T411 D816 D383 T385 D541
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
Biological Process
GO:0006869 lipid transport
GO:0015914 phospholipid transport
GO:0034220 monoatomic ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0031901 early endosome membrane
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bss, PDBe:7bss, PDBj:7bss
PDBsum7bss
PubMed32997992
UniProtQ8NB49|AT11C_HUMAN Phospholipid-transporting ATPase IG (Gene Name=ATP11C)

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